Gizmorama!

Good Morning,

Is it me, or does it seem like stories about “climate
changes” pop up more and more? I know I ran a story about
“climate changes” already this week and now here’s another
one. This time drastic climate changes may alter the
patterns of wildfires worldwide.

What will climate changes do next?

Until Tomorrow,
Erin

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——— Skin immune cells fight infection well ———-

MELBOURNE - Australian scientists say they’ve discovered
immune cells in the skin might improve treatment of viral
skin infections. University of Melbourne researchers said
they identified previously unrecognized first-line defense
mechanisms that are important at portals of viral and bact-
erial entry, such as the skin and the gut. They conducted
their research using a model infection with herpes simplex
virus. The work was published in two articles in the
advanced online March and April editions of the journal
Nature Immunology. The April article details findings on
the function of the cells that trigger the initial immune
response to viral infection — known as dendritic cells.
The results could not only provide help in the treatment
of viral skin infections but also of auto-immune diseases
such as psoriasis, said Sammy Bedoui, lead author of the
April paper. The March paper focuses on the post-infection
stage when some memory T cells retain the ability to
recognize the shape of the virus or bacteria. “Because
the cells are located at the site of infection, they can
respond instantly, much faster than other immune cells
that have to travel via the blood to the site,” said
Thomas Gebhardt, the lead author of the March paper. “This
debunks previous thought that immunity by T cells only
occurs at longer distances throughout the body.”

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——– Altered gene increases schizophrenia risk ———

NEW BRUNSWICK, N.J. - U.S. geneticists say they’ve
identified a specific DNA change that is likely to
increase the risk of some people developing schizophrenia.
The researchers, led by Rutgers University Professor Linda
Brzustowicz, said the gene, NOS1AP (previously known as
CAPON) provides a potential mechanism that might be a
point of entry for drug therapy, consistent with the
growing trend of personalized medicine. Brzustowicz,
a psychiatrist, said the research has demonstrated a
functional DNA change that increases gene expression. That
conclusion is based on its presence in the genes of a
Canadian study population of 24 families in which multiple
individuals were diagnosed with schizophrenia. The paper
also presents an innovative statistical method, Posterior
Probability of Linkage Disequilibrium, by study co-author
Veronica Vieland of The Research Institute at Nationwide
Children’s Hospital in Columbus, Ohio. The analytical
technique quantifies the statistical evidence for
association, in this case between the altered gene and
schizophrenia. Brzustowicz said she and her team will now
look at the altered gene’s frequency in DNA samples from
the National Institute of Mental Health collection of
cell lines that include samples drawn from large
populations of Asian, Caucasian, African American and
Hispanic individuals with schizophrenia.

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——- Climate change may alter wildfire patterns ——–

BERKELEY, Calif. - A University of California-Berkeley and
Texas Tech University study suggests climate change will
result in major shifts of worldwide fire patterns. In
research, called the first of its kind, scientists used
European Space Agency thermal-infrared satellite sensor
data in their global study of pyrogeography — the
distribution and behavior of wildfire. “This is the first
attempt to quantitatively model why we see fire where we
see it across the entire planet,” said study author Max
Moritz, co-director of the Cal-Berkeley’s Center for Fire
Research and Outreach. “What is startling in these findings
is the relatively rapid rate at which we’re likely to see
very broad-scale changes in fire activity for large parts
of the planet.” The researchers said their preliminary
results show hot spots of fire invasion forming in parts
of the western United States and the Tibetan plateau, while
other regions including northeast China and central Africa
might become less fire-prone. The researchers said their
findings are a first step towards creating a comprehensive
picture of how climate change will alter fire risk around
the world if drastic cuts in greenhouse gas emissions don’t
occur. The study is available in the online journal PLoS
One.

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