Gizmorama!

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“The Cutting Edge of Science Fact and Science Possibilities”
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Good Morning,

One of todays’ articles is about researches seek-
ing studies on pregnancy.

Have A Good Day!

Until Tomorrow,
Erin

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          Researchers seek studies on pregnancy

U.S. researchers say some pregnant women may suffer
serious health problems because so little is known
about how they react to prescribed medications. “I
can’t identify any other group that has been as
systematically neglected” in biomedical research,
said Ruth Faden, who heads the Johns Hopkins Berman
Institute of Bioethics in Baltimore. Many research
programs consider pregnant women off-limits, but
there are new fears that leaving health problems un-
treated could be more dangerous for the mother and
fetus than taking unstudied medications, said Faden.
While few drugs are approved for use during pregnancy,
millions of pregnant women annually take medication
to control blood pressure, depression or cancer with-
out meaningful research having been done on whether
the drugs are safe for them and their fetuses, The
Baltimore Sun reported Sunday. “It’s really contro-
versial,” said Dr. Donald Mattison of the National
Institute of Child Health and Human Development.
“There are some groups who believe it’s completely
inappropriate, and others who are outraged that
more hasn’t been done.”

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       Scientists decode cancer patient’s DNA

Scientists in St. Louis say they have decoded the com-
plete DNA of a cancer patient and traced her disease
– acute myelogenous leukemia — to its genetic roots.
The research team at the Genome Sequencing Center and
the Siteman Cancer Center at Washington University
School of Medicine in St. Louis said the first-of-its-
kind achievement involved sequencing the genome of the
patient — a woman in her 50s who ultimately died of
her disease — and the genome of her leukemia cells,
to identify genetic changes unique to her cancer. “Our
work demonstrates the power of sequencing entire gen-
omes to discover novel cancer-related mutations,” said
senior author Richard Wilson, director of Washington
University’s Genome Sequencing Center. “A genome-wide
understanding of cancer, which is now possible with
faster, less expensive DNA sequencing technology, is
the foundation for developing more effective ways to
diagnose and treat cancer.” The study appears in the
journal Nature.

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         Study links genes to brain aneurysms

A U.S.-led team of scientists has found three chro-
mosome segments, or loci, where common genetic vari-
ations can create a significant risk of brain aneur-
ysms. Yale University medical scientists said their
finding represents a large step toward unraveling the
mysteries of brain aneurysms, the often fatal ruptur-
ing of blood vessels that afflicts 500,000 people
worldwide each year and nearly killed U.S. Vice
President-elect Joe Biden two decades ago. The inter-
national team led by Dr. Murat Gunel and Dr. Richard
Lifton scanned the genomes of more than 2,000 people
suffering intracranial aneurysms along with 8,000
healthy subjects. The subjects were from hospitals in
Finland, the Netherlands and Japan, and the results
were similar in all groups, indicating the variations
increase risk among diverse human populations. “Even
though we have made significant strides in treating
unruptured aneurysms, until now we have not had an
effective means of identifying the majority of in-
dividuals at risk of developing this deadly problem,”
said Gunel. “These genetic findings provide a start-
ing point for changing that equation.” The research
that included Kaya Bilguvar, Shrikant Mane,
Christopher Mason, Murim Choi, Emilia Gaal, Yasa
Bayri, Luis Kobl, Zulfikar Arlier, Sudhakar Ravuri
and Matthew State appears online in the journal
Nature Genetics.