Gizmorama!

Good Morning,

For as long as I’ve been doing this newsletter there never
seems to be a shortage of material to share. We live in an
incredible age where the sky is no longer the limit and
just about anything is possible.

Today alone there are stories about new treatments in pain
management, dangerous discoveries in some sea-life and the
possible launch of “microsatellites” to monitor such things
as “…weather, disasters and traffic…”

The possibilities seem endless.

Until Tomorrow,
Erin

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——– New nerve block may change pain management ——–

BOSTON - Children’s Hospital Boston scientists say they’ve
created a slow-release anesthetic drug-delivery system
that could potentially revolutionize pain treatment. The
researchers said their National Institutes of Health-funded
work might change the way physicians treat pain during and
after surgery, as well chronic pain. The scientists said
they used specially designed fat-based particles called
liposomes to package saxitoxin, a potent anesthetic, and
produced long-lasting local anesthesia in rats without
apparent toxicity to nerve or muscle cells. “The idea was
to have a single injection that could produce a nerve block
lasting days, weeks, maybe even months,” said Dr. Daniel
Kohane, the report’s senior author. “It would be useful
for conditions like chronic pain where, rather than use
narcotics (that) are systemic and pose a risk of addiction,
you could just put that piece of the body to sleep, so to
speak.” The scientists said previous attempts to develop
slow-release anesthetics haven’t been successful due to
toxicity problems. But in the new study, Kohane and his
colleagues report saxitoxin packaged within liposomes is
able to block nerve transmission of pain without causing
significant nerve or muscle damage. Kohane said he is now
optimizing the formulation to make it last even longer and
it is conceivable clinical trials could soon start. The
research appears in the online edition of the Proceedings
of the National Academy of Sciences.

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——— Study finds all octopuses are venomous ———-

MELBOURNE - Researchers from Australia and Belgium say
they have determined all octopuses, cuttlefish and some
squid are venomous. The scientists at the University of
Melbourne, University of Brussels and Museum Victoria
said their discovery indicates the octopus, cuttlefish
and squid share a common, ancient venomous ancestor.
Bryan Fry, director of the University of Melbourne’s
Australian Venom Research Unit, said that while the blue-
ringed octopus is the only octopus that’s dangerous to
humans, the other species have been using their venom for
predation, such as paralyzing a clam into opening its
shell. “Venoms are toxic proteins with specialized
functions, such as paralyzing the nervous system,” Fry
said. “We hope that by understanding the structure and
mode of action of venom proteins we can benefit drug
design for a range of conditions such as pain management,
allergies and cancer.” Fry said that while many creatures
have been examined as a basis for drug development,
cephalopods (octopuses, cuttlefish and squid) remain
an untapped resource and their venom might represent a
unique class of compounds. The research appears in the
Journal of Molecular Evolution.

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——— Japan considers launching satellites ———–

TOKYO - The Japanese government is considering the use of
100 so-called microsatellites to monitor weather, disasters
and traffic, officials said. The Yomiuri Shimbun reported
Thursday that a plan calls for the creation a cluster of
as many as 100 microsatellites in low orbit to aid in
government observations. Officials at the Japanese
Education, Science and Technology Ministry and the Economy,
Trade and Industry Ministry say they hope the technology
will help authorities better track storms, crops and
traffic conditions. The government plan calls for a launch
of 50 to 100 microsatellites to create the observation
cluster in two years at the earliest. A ministry official
said the government would like to use an “inexpensive”
Russian rocket to launch the satellites.

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